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Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training

However, factors like stress, pollution, poor diet, and ageing reduce glutathione levels

10.1136/bcr-2017-220928 256

Compared with those in the control group, the expression levels of GPX4 and GSH in the uterus and placenta of PCOS rats were lower, and the expression levels of the ferroptosis-related genes ACSL4, TFCR1, SLC7A11, and glutamate cysteine ligase C were significantly increased (127)

How the amount and/or activity of these proteins are regulated under various conditions though, needs to be further determined

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